By Silvio Garattini
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Extra info for Advances in Pharmacology and Chemotherapy Volume 7
Residual enzymatic ootivity and antigenic determinants occurred in three subjects who revealed a single band on the starch gel a t the C-4position when their sera were concentrated 6-fold. I n the remaining two cases, results similar to those of Hodgkin et al. were obtained. C-utsche, Scott, and Wright (1967)reported a high incidence of the silent mutation in a population of southern Eskimos. Nineteen cases in 11 Eskimo families were ascertained as a result of apnea in 2 Eskimo children after a single low dose of succinylcholine.
Alternatively, both drugs may be degraded by similar enzymatic steps. Whatever the explanation, the existence of such a correlation raises the possibility that \\ithin an individual the rates of metabolism of other drugs may also be correlated. Recent work by Hammer et al. (1969)demonstrates correlation of the rates of 14 ELLIOT S. VESELL metabolism of desmethylimipramine, nortriptyline, and oxyphenylbutazone. The close correlation between the rates of metabolism of these three drugs is strikingly illustrated in Fig.
And mother E. J. ) hydroxylated normally and apparently, therefore, by enzymes different from those that hydroxylate Dilantin. However, since urinary excretion of unaltered phenobarbital (Butler, 1956) occurs in higher amounts, reaching 30% of the daily intake, than does Dilantin, which attains only 5y0of daily intake, Kutt et al. (1964a) suggest that phenobarbital accumulation is less likely t o occur and therefore a hydroxylation defect may be masked. The observations of Kutt et al. (1964a)on the family with deficient hydroxylation of Dilantin indicate that when toxic symptoms develop, particularly with low dosages, determinations of blood levels and urinary metabolites of Dilantin should be performed.
Advances in Pharmacology and Chemotherapy Volume 7 by Silvio Garattini