Gilles Grateau, Robert A. Kyle, Martha Skinner's Amyloid and amyloidosis PDF

By Gilles Grateau, Robert A. Kyle, Martha Skinner

ISBN-10: 0849335345

ISBN-13: 9780849335341

This authoritative quantity comprises 179 chapters via overseas specialists on contemporary advancements in our knowing of amyloid proteins, protein folding issues, and new and proposed scientific trials in amyloidosis. themes comprise detection and characterization concepts; organic capabilities; genetics; problems, analysis, and coverings, together with organ transplants and drug cures; effects from vast scientific stories; and epidemiology. this can be a beneficial source for clinicians who deal with sufferers with systemic and localized sorts of amyloidosis, and for researchers in biochemistry, neurobiology, and telephone biology.

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1996), Fold. , 1, 325. M. J. , 10, 905. , Ptak M. and Vovelle F. (1997), Fold. , 2, 183. Godzik A. , 44, 525. Skolnick J. and Kihara D. (2000), Proteins: Struct. Funct. , 42, 319. , Marchler-Bauer A. H. (2000), J. Mol. , 296, 1319. V. and Luthey-Schulten Z. (2002), Curr. Opin. Struct. , 12, 176. Tramontano A. and Morea V. (2003), Proteins: Struct. Funct. , 53, 352. , Cheng H. V. (2003), Proteins: Struct. Funct. , 53, 395. , Hadley C. B. (2003), Proteins: Struct. Funct. , 53, 436. J. W. (2000), Nature, 407, 923.

RESULTS AND DISCUSSION Positive samples included tissues positive for amyloid by Congo red stain (with apple-green birefringence under polarized light) and deposits that were fibrillar by electron microscopy. We tested myocardium containing ATTR and AL-lambda and kidney (cortex and medulla) containing ATTR and AL-lambda and AL-lambda amyloidoma of the urinary bladder. Typing of amyloid deposits in frozen sections was performed against a panel of antibodies and evaluated by immunofluorescence. ATTR was derived from wild type transthyretin as confirmed by DNA sequencing.

After diluting the aggregated sample to 5% TFE(Figure 2b), the partially unfolded dis dis protein is responsible for the observed burst phase (Burst-P ), the globular aggregates for the fast phase (k1 ) and clusters of globular aggregates for the slow phase (k dis 2 ). The larger superstructures cannot be disrupted under the conditions used here. THERAPEUTIC IMPLICATIONS Reversion of misfolded proteins to their native state and clearance of amyloid deposits by destabilization of the aggregates have been shown to be winning therapeutic strategies to treat both neurodegenerative and systemic diseases related to protein aggregation (2-3).

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Amyloid and amyloidosis by Gilles Grateau, Robert A. Kyle, Martha Skinner


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