Download e-book for iPad: Antimicrobial drug discovery : emerging strategies by George Tegos, Eleftherios Mylonakis

By George Tegos, Eleftherios Mylonakis

ISBN-10: 1845939433

ISBN-13: 9781845939434

Drug resistance is expanding between various human pathogenic microorganisms corresponding to Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as probably the most vital medical demanding situations of this century. elevated basic expertise and worry of those pathogens potential there's a growing to be call for for learn to take on the specter of multidrug resistance. Documenting the most recent examine within the box, this ebook discusses present and promising actions to find new antimicrobials in 5 key components: molecular genetics and platforms microbiology; man made, computational chemistry and chemoinformatics; excessive Throughput Screening (HTS); non-vertebrate version hosts; and lightweight- and nano-based applied sciences.

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Barbe, J. M. (2004) Inhibitors of antibiotic efflux in resistant Enterobacter aerogenes and Klebsiella pneumoniae strains. Antimicrobial Agents and Chemotherapy 48, 1043–1046. Y. C. (2011) Candida albicans vs. non-albicans bloodstream infections: the comparison of risk factors and outcome. Journal of Microbiology, Immunology and Infection 44, 369–375. K. S. (2010) In vitro photodynamic antimicrobial activity of methylene blue and endoscopic white light against Helicobacter pylori 26695. Journal of Photochemistry and Photobiology B: Biology 101, 206–209.

Trends in Microbiology 13, 119–127. , Chopra, I. W. (2010) Structure-based discovery of antibacterial drugs. Nature Reviews Microbiology 8, 501–510. , Roncucci, G. and Jori, G. (2002) Approaches to selectivity in the Zn(II)-phthalocyaninephotosensitized inactivation of wild-type and antibiotic-resistant Staphylococcus aureus. Photochemical and Photobiological Sciences 1, 815–819. Soukos, N. M. (2011) Photodynamic therapy in the control of oral biofilms. Periodontology 2000 55, 143–166. V. and Gibbons, S.

R. (2004) Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitis. Infection and Immunity 72, 3628–3633. R. P. (2011) Antimicrobial and efflux pump inhibitory activity of caffeoylquinic acids from Artemisia absinthium against Grampositive pathogenic bacteria PLoS One 6, e18127. Finlay, B. and Falkow, S. (1997) Common themes in microbial pathogenicity revisited. Microbiology and Molecular Biology Reviews 61, 136–169. A. (2005) Bacteriophage lytic enzymes: novel anti-infectives.

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Antimicrobial drug discovery : emerging strategies by George Tegos, Eleftherios Mylonakis

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