By George Tegos, Eleftherios Mylonakis
Drug resistance is expanding between various human pathogenic microorganisms corresponding to Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as probably the most vital medical demanding situations of this century. elevated basic expertise and worry of those pathogens potential there's a growing to be call for for learn to take on the specter of multidrug resistance. Documenting the most recent examine within the box, this ebook discusses present and promising actions to find new antimicrobials in 5 key components: molecular genetics and platforms microbiology; man made, computational chemistry and chemoinformatics; excessive Throughput Screening (HTS); non-vertebrate version hosts; and lightweight- and nano-based applied sciences.
Read or Download Antimicrobial drug discovery : emerging strategies PDF
Similar basic science books
This moment variation keeps to innovatively assessment the hardest options in biochemistry for optimum comprehension in a brief time period. not like traditional texts or overview books that pressure memorizing proof, simple techniques stresses the studying of primary suggestions, in order that the reader actually comprehends the fabric and feels cozy making use of it.
Kurzbeschreibung Der Embryologie-Klassiker in neuer Auflage! Die deutsche Übersetzung des englischen Klassikers ist ein umfassendes Lehrbuch zur Embryologie und Teratologie des Menschen, das darüber hinaus auch noch klinisch orientiert die Sachverhalte näher bringt. Woche für Woche, Stadium für Stadium erfahren Sie, wie sich die Organe und Systeme entwickeln und wann und wie Fehlbildungen entstehen.
The detection and dimension of the dynamic interactions of proteins in the residing mobile are severe to our figuring out of phone body structure and pathophysiology. With be anxious microscopy and spectroscopy concepts, simple and medical scientists could make such measurements at very excessive spatial and temporal answer.
Contemporary growth in Hormone learn, quantity 26 covers the lawsuits of the twenty seventh annual assembly of the Laurentian Hormone convention held at Mont Tremblant, Quebec, Canada on August 24-29, 1969. The e-book offers papers at the pituitary and gonadal hormones in girls in the course of spontaneous and prompted ovulatory cycles; the mechanisms regulating the menstrual cycle in ladies; a few actual and hydrodynamic homes of human FSH and LH; and the organic importance of the prostaglandins.
Additional info for Antimicrobial drug discovery : emerging strategies
Barbe, J. M. (2004) Inhibitors of antibiotic efflux in resistant Enterobacter aerogenes and Klebsiella pneumoniae strains. Antimicrobial Agents and Chemotherapy 48, 1043–1046. Y. C. (2011) Candida albicans vs. non-albicans bloodstream infections: the comparison of risk factors and outcome. Journal of Microbiology, Immunology and Infection 44, 369–375. K. S. (2010) In vitro photodynamic antimicrobial activity of methylene blue and endoscopic white light against Helicobacter pylori 26695. Journal of Photochemistry and Photobiology B: Biology 101, 206–209.
Trends in Microbiology 13, 119–127. , Chopra, I. W. (2010) Structure-based discovery of antibacterial drugs. Nature Reviews Microbiology 8, 501–510. , Roncucci, G. and Jori, G. (2002) Approaches to selectivity in the Zn(II)-phthalocyaninephotosensitized inactivation of wild-type and antibiotic-resistant Staphylococcus aureus. Photochemical and Photobiological Sciences 1, 815–819. Soukos, N. M. (2011) Photodynamic therapy in the control of oral biofilms. Periodontology 2000 55, 143–166. V. and Gibbons, S.
R. (2004) Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitis. Infection and Immunity 72, 3628–3633. R. P. (2011) Antimicrobial and efflux pump inhibitory activity of caffeoylquinic acids from Artemisia absinthium against Grampositive pathogenic bacteria PLoS One 6, e18127. Finlay, B. and Falkow, S. (1997) Common themes in microbial pathogenicity revisited. Microbiology and Molecular Biology Reviews 61, 136–169. A. (2005) Bacteriophage lytic enzymes: novel anti-infectives.
Antimicrobial drug discovery : emerging strategies by George Tegos, Eleftherios Mylonakis