By Jacqueline A. Hubbard, Devin K. Binder
Epilepsy is a devastating workforce of neurological problems characterised via periodic and unpredictable seizure job within the brain. there's a serious desire for brand spanking new medicinal drugs and methods given than not less than one-third of all epilepsy sufferers aren't made freed from seizures by way of current medicines and develop into "medically refractory". a lot of epilepsy study has taken with neuronal healing objectives, yet present antiepileptic medications frequently reason serious cognitive, developmental, and behavioral unwanted effects. contemporary findings point out a serious contribution of astrocytes, star-shaped glial cells within the mind, to neuronal and community excitability and seizure activity. in addition, many very important mobile and molecular adjustments ensue in astrocytes in epileptic tissue in either people and animal types of epilepsy. The objective of Astrocytes and Epilepsy is to comprehensively assessment intriguing findings linking alterations in astrocytes to useful alterations accountable for epilepsy for the 1st time in e-book format. those insights into astrocyte contribution to seizure susceptibility point out that astrocytes may perhaps signify a massive new healing aim within the keep an eye on of epilepsy.
Astrocytes and Epilepsy comprises history explanatory textual content on astrocyte morphology and body structure, epilepsy versions and syndromes, and proof from either human tissue reports and animal versions linking sensible alterations in astrocytes to epilepsy. fantastically labelled diagrams are awarded and proper figures from the literature are reproduced to explain key findings and ideas during this quickly rising field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators in addition to neurologists and different experts taking care of sufferers with epilepsy.
- Presents the 1st complete ebook to synthesize ancient and up to date learn on astrocytes and epilepsy into one coherent volume
- Provides a good source at the box of astrocyte biology and astrocyte-neuron interactions
- Details capability healing pursuits, together with chapters on hole junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation
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Extra resources for Astrocytes and Epilepsy
For the first time, this clearly distinguished two cell types with distinct cytoplasmic expansions, which Río-Hortega termed microglia and oligodendroglia. 23 Santiago Ramón y Cajal (1852–1934) in his laboratory. 24 Penfield (lower row, second from left) and Rίo-Hortega (lower row, center) in Spain with colleagues, 1924. Source: Reproduced with permission from Gill AS, Binder DK. Wilder Penfield, Pío del Río-Hortega, and the discovery of oligodendroglia. Neurosurgery 2007;60(5):940–8. could be divided into four classes: (1) fibrous neuroglia; (2) protoplasmic neuroglia; (3) microglia; and (4) oligodendroglia.
1873;33:244–246. ASTROCYTES AND EPILEPSY 36 1. History of Astrocytes  Golgi C. Opera omnia. Milano: Hoepli; 1903.  Golgi C. Contribuzione alla fina Anatomia degli organi centrali del sistema nervosos. Rivista clinica di Bologna; 1872;2:38–46.  Ramón y Cajal S. Contribución al conocimiento de la neuroglia del cerebro humano. Trab Lab Invest Biol 1913;11:255–315.  Del Río-Hortega P. El tercer elemento de los centros nerviosos. Bol Soc Esp Biol 1919;9:69–120.  Lenhossék Mv. Der feinere Bau des Nervensystems im Lichte neuester Forschung.
In deep irony, in the late 1920s Penfield’s older sister Ruth Inglis developed an oligodendroglioma, a tumor of the same cell type that Penfield had substantiated in Madrid. Interestingly, on describing a tumor resection in a letter to his mother in 1921, Penfield had stated, “Brain surgery is a terrible profession. If I did not feel it would become very different in my lifetime, I should hate it” . Despite craniotomies for resection of her tumor by Penfield on December 11, 1928 and for recurrence by Harvey Cushing on November 6, 1930, Ruth ultimately died in September 1931.
Astrocytes and Epilepsy by Jacqueline A. Hubbard, Devin K. Binder